Tg(CMV-EGFP,Rnu6-siAbca1)#Wcyy
Transgene Detail

Summary

• Symbol: Tg(CMV-EGFP,Rnu6-siAbca1)#Wcyy
• Name: transgene insertion, Winston C Y Yu
• MGI ID: MGI:3510918
• Synonyms: SIRIUS-ABCA1
• Transgene: Tg(CMV-EGFP,Rnu6-siAbca1)#Wcyy Location: unknown
• Alliance: Tg(CMV-EGFP,Rnu6-siAbca1)#Wcyy page

Transgene origin

• Strain of Origin: ICR

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene consists of the mouse Rnu6 promoter, a loxP site, a CMV promoter, EGFP, and an Abca1 siRNA. Without cre mediated recombination only EGFP is expressed. After cre mediated recombination the Abca1 siRNA is expressed. Six founders were generated. (J:93624)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:93624 Chang HS, et al., Using siRNA technique to generate transgenic animals with spatiotemporal and conditional gene knockdown. Am J Pathol. 2004 Nov;165(5):1535-41
• All: 1 reference(s)