Lat2tm1Wz
Targeted Allele Detail
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Symbol: |
Lat2tm1Wz |
Name: |
linker for activation of T cells family, member 2; targeted mutation 1, Weiguo Zhang |
MGI ID: |
MGI:3510962 |
Synonyms: |
LAB-, NLATKO |
Gene: |
Lat2 Location: Chr5:134628876-134643879 bp, - strand Genetic Position: Chr5, 74.7 cM
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Alliance: |
Lat2tm1Wz page
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Germline Transmission: |
Earliest citation of germline transmission:
J:93951
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 2-8 were replaced with a neomycin resistance gene. The deleted region encoded the 5' terminal from residues 1-113, including the transmembrane domain and palmitoylation site. Immunoprecipitation of protein from splenocyte and mast cell lysates followed by immunoblot confirmed the absence of protein in mutants.
(J:93951)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Lat2 Mutation: |
19 strains or lines available
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Original: |
J:93951 Zhu M, et al., Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL. J Exp Med. 2004 Oct 18;200(8):991-1000 |
All: |
9 reference(s) |
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