Slc3a2^tm1Yai
Targeted Allele Detail

Summary

• Symbol: Slc3a2^tm1Yai
• Name: solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2; targeted mutation 1, Yasuhiko Ito
• MGI ID: MGI:3511126
• Synonyms: CD98^-
• Gene: Slc3a2 Location: Chr19:8684931-8700733 bp, - strand Genetic Position: Chr19, 5.44 cM
• Alliance: Slc3a2^tm1Yai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93968
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Aberrant recombination resulted in the insertion of a neo cassette between intron 2 and the 5' arm of the heavy chain. Northern blot analysis showed the presence of an aberrant transcript in heterozygous mice. (J:93968)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc3a2 Mutation: 39 strains or lines available

References

• Original: J:93968 Tsumura H, et al., The targeted disruption of the CD98 gene results in embryonic lethality. Biochem Biophys Res Commun. 2003 Sep 5;308(4):847-51
• All: 2 reference(s)