Syngap1^tm1.1Mabk
Targeted Allele Detail

Summary

• Symbol: Syngap1^tm1.1Mabk
• Name: synaptic Ras GTPase activating protein 1 homolog (rat); targeted mutation 1.1, Mary B Kennedy
• MGI ID: MGI:3511175
• Synonyms: SG^-, synGAP^-, Syngap1^tm1Mabk
• Gene: Syngap1 Location: Chr17:27160227-27191408 bp, + strand Genetic Position: Chr17, 13.6 cM
• Alliance: Syngap1^tm1.1Mabk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93969
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A neo cassette flanked by loxP sites inserted into intron 3 and an additional loxP site within exon 9 via homologous recombination. Expression of Cre recombinase in recombinant ES cells resulted in the deletion of exons 4-9. Western blot analysis confirmed the absence of protein in hippocampal homogenates at P0 and in hippocampal neurons cultured for 10 days. (J:93969)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Syngap1 Mutation: 49 strains or lines available

References

• Original: J:93969 Vazquez LE, et al., SynGAP regulates spine formation. J Neurosci. 2004 Oct 6;24(40):8862-72
• All: 9 reference(s)