Cops5^tm1Jka
Targeted Allele Detail

Summary

• Symbol: Cops5^tm1Jka
• Name: COP9 signalosome subunit 5; targeted mutation 1, Jun-ya Kato
• MGI ID: MGI:3511260
• Synonyms: Jab1^-
• Gene: Cops5 Location: Chr1:10094825-10108384 bp, - strand Genetic Position: Chr1, 2.29 cM
• Alliance: Cops5^tm1Jka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93979
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo marker gene replaced exons 1-6, including the start codon, via homologous recombination. Western analysis using an antibody that recognized the C terminus did not detect truncated polypeptides from the putative open reading frame in exons 7 and 8. (J:93979)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cops5 Mutation: 25 strains or lines available

References

• Original: J:93979 Tomoda K, et al., Multiple functions of Jab1 are required for early embryonic development and growth potential in mice. J Biol Chem. 2004 Oct 8;279(41):43013-8
• All: 3 reference(s)