Fcer2a^Hie
Spontaneous Allele Detail

Summary

• Symbol: Fcer2a^Hie
• Name: Fc receptor, IgE, low affinity II, alpha polypeptide; hyper IgE
• MGI ID: MGI:3511262
• Gene: Fcer2a Location: Chr8:3731737-3744175 bp, - strand Genetic Position: Chr8, 1.92 cM, cytoband A1
• Alliance: Fcer2a^Hie page

Mutation origin

• Strain of Origin: NZB

Mutation description

• Allele Type: Spontaneous
• Mutation: Nucleotide substitutions
• Mutation details: This allele was first described as having four point mutations: A82T, V87A, S258L, and D301N. The first two mutations are in the most N-terminal of the four homologous repeats of the stalk region and are predicted to form an alpha-helical coiled-coil arrangement on trimerisation. S258L is in a region essential for IgE binding. A later study revealed a fifth point mutation, K131E, that occurs in the stalk region. This allele is found in mice of 129 or NZB origin. (J:93999, J:142807)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fcer2a Mutation: 24 strains or lines available

References

• Original: J:93999 Lewis G, et al., Hyper IgE in New Zealand black mice due to a dominant-negative CD23 mutation. Immunogenetics. 2004 Nov;56(8):564-71
• All: 2 reference(s)