Lepr^tm1Chua
Targeted Allele Detail

Summary

• Symbol: Lepr^tm1Chua
• Name: leptin receptor; targeted mutation 1, Streamson C Chua, Jr
• MGI ID: MGI:3511283
• Synonyms: Lepr^neo
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^tm1Chua page

Obesity in Lepr^tm1Chua/Lepr^tm1Chua mice (center) and normal weight in Lepr^tm1.1Chua/Lepr^tm1.1Chua (left)

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94019
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP-frt-PGK-neo-frt cassette was inserted into intron 16 and a second loxP site was placed in exon 17. (J:94019)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 122 strains or lines available

References

• Original: J:94019 McMinn JE, et al., An allelic series for the leptin receptor gene generated by CRE and FLP recombinase. Mamm Genome. 2004 Sep;15(9):677-85
• All: 10 reference(s)