Ppargc1a^tm1Brsp
Targeted Allele Detail

Summary

• Symbol: Ppargc1a^tm1Brsp
• Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; targeted mutation 1, Bruce M Spiegelman
• MGI ID: MGI:3511352
• Synonyms: PGC-1alpha^-
• Gene: Ppargc1a Location: Chr5:51611592-51725068 bp, - strand Genetic Position: Chr5, 27.02 cM, cytoband C1
• Alliance: Ppargc1a^tm1Brsp page

Ppargc1a^tm1Brsp/Ppargc1a^tm1Brsp mice develop dilated cardiomyopathy in response to transverse aortic constriciton (TAC)

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93896
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele resulted from the crossing of Ppargc1a^tm2Brsp with mice expressing cre recombinase in the germline. Exons 3-5 were removed from the locus. Northern and Western blot analyses indicated a lack of transcript and protein in mutants. (J:93896)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ppargc1a Mutation: 48 strains or lines available

References

• Original: J:93896 Lin J, et al., Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell. 2004 Oct 1;119(1):121-35
• All: 90 reference(s)