Pparg^tm3(tTA)Yba
Targeted Allele Detail

Summary

• Symbol: Pparg^tm3(tTA)Yba
• Name: peroxisome proliferator activated receptor gamma; targeted mutation 3, Yaacob Barak
• MGI ID: MGI:3511359
• Synonyms: Pparg^tm3Yba, Pparg^tTA
• Gene: Pparg Location: Chr6:115337912-115467360 bp, + strand Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
• Alliance: Pparg^tm3(tTA)Yba page

Mild lipodystrophy with modest metabolic anomalies in Pparg^tm3(tTA)Yba/Pparg⁺ mice compared to Pparg^tm2(tTA)Yba/Pparg⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125992
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Transactivator)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with an IRES, tTA and neo cassette. While expression is modest in adipose tissue, it is poor in the liver and placenta. (J:125992)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pparg Mutation: 41 strains or lines available

References

• Original: J:125992 Kim S, et al., A mouse model of conditional lipodystrophy. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16627-32
• All: 4 reference(s)