Pdgfrb^tm1Rheu
Targeted Allele Detail

Summary

• Symbol: Pdgfrb^tm1Rheu
• Name: platelet derived growth factor receptor, beta polypeptide; targeted mutation 1, Rainer Heuchel
• MGI ID: MGI:3511432
• Synonyms: D849N
• Gene: Pdgfrb Location: Chr18:61178222-61218133 bp, + strand Genetic Position: Chr18, 34.41 cM
• Alliance: Pdgfrb^tm1Rheu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93973
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: A G to A transition resulting in an amino acid change of D849N was introduced in exon 17 via homologous recombination. A loxP-flanked PGK-neo expression cassette was also inserted in intron 15. (J:93973)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdgfrb Mutation: 87 strains or lines available

References

• Original: J:93973 Chiara F, et al., A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity. J Biol Chem. 2004 Oct 8;279(41):42516-27
• All: 3 reference(s)