Traf2^tm1Rbr
Targeted Allele Detail

Summary

• Symbol: Traf2^tm1Rbr
• Name: TNF receptor-associated factor 2; targeted mutation 1, Robert Brink
• MGI ID: MGI:3511494
• Synonyms: Traf2^lox
• Gene: Traf2 Location: Chr2:25407994-25436952 bp, - strand Genetic Position: Chr2, 17.32 cM
• Alliance: Traf2^tm1Rbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93890
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 3 was flanked by loxP sites followed by a floxed neo cassette. The neo cassette was removed in ES cells by transient transfection with a vector driving expression of Cre recombinase, leaving exon 3 flanked by loxP sites. Western blot analysis of lymph node B cells showed that expression levels did not differ from that of wild-type. (J:93890)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Traf2 Mutation: 25 strains or lines available

References

• Original: J:93890 Grech AP, et al., TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells. Immunity. 2004 Nov;21(5):629-42
• All: 21 reference(s)