Traf2^tm1.1Rbr
Targeted Allele Detail

Summary

• Symbol: Traf2^tm1.1Rbr
• Name: TNF receptor-associated factor 2; targeted mutation 1.1, Robert Brink
• MGI ID: MGI:3511496
• Synonyms: Traf2^delta
• Gene: Traf2 Location: Chr2:25407994-25436952 bp, - strand Genetic Position: Chr2, 17.32 cM
• Alliance: Traf2^tm1.1Rbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93890
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated by removing the floxed exon 3 from Traf2^tm1Rbr via transient expression of Cre recombinase in recombinant ES cells. Excision of exon 3 resulted in a reading frame shift and introduced a premature stop codon. (J:93890)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Traf2 Mutation: 25 strains or lines available

References

• Original: J:93890 Grech AP, et al., TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells. Immunity. 2004 Nov;21(5):629-42
• All: 2 reference(s)