Sv2b^tm1Baj
Targeted Allele Detail

Summary

• Symbol: Sv2b^tm1Baj
• Name: synaptic vesicle glycoprotein 2b; targeted mutation 1, Sandra M Bajjalieh
• MGI ID: MGI:3511830
• Gene: Sv2b Location: Chr7:74764642-74959010 bp, - strand Genetic Position: Chr7, 43.62 cM, cytoband D1
• Alliance: Sv2b^tm1Baj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70828
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neomycin gene replaced the first coding exon and flanking sequences. Northern blot of of homozygote brain extracts indicated the presence of a truncated mRNA. Western blot analysis of brain homogenates derived from homozygous mice confirmed that no detectable encoded protein was made though the only available antibodies target the amino terminus. (J:148272)

Generation of the Sv2b^tm1Baj allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Sv2b Mutation: 58 strains or lines available

References

• Original: J:70828 Xu T, et al., SV2 modulates the size of the readily releasable pool of secretory vesicles. Nat Cell Biol. 2001 Aug;3(8):691-8
• All: 8 reference(s)