Myo7a^Hdb
Chemically induced Allele Detail

Summary

• Symbol: Myo7a^Hdb
• Name: myosin VIIA; headbanger
• MGI ID: MGI:3511858
• Synonyms: ABE6
• Gene: Myo7a Location: Chr7:97700267-97768731 bp, - strand Genetic Position: Chr7, 53.57 cM
• Alliance: Myo7a^Hdb page

Stereocilia defects in Myo7a^Hdb/Myo7a⁺ mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: An A to T transversion at position 531 in exon 6 of Myo7a was identified and is predicted to cause an isoleucine-to-phenylalanine amino acid substitution at position 178, however no evidence of complementation was found when homozygotes were mated with heterozygous Myo7a^4626SB. (J:93998)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myo7a Mutation: 118 strains or lines available

References

• Original: J:93998 Rhodes CR, et al., A Myo7a mutation cosegregates with stereocilia defects and low-frequency hearing impairment. Mamm Genome. 2004 Sep;15(9):686-97
• All: 6 reference(s)