Rps6kb1^tm1Nte
Targeted Allele Detail

Summary

• Symbol: Rps6kb1^tm1Nte
• Name: ribosomal protein S6 kinase, polypeptide 1; targeted mutation 1, Naohiro Terada
• MGI ID: MGI:3511860
• Synonyms: p70^s6k, p85^s6k
• Gene: Rps6kb1 Location: Chr11:86389697-86435631 bp, - strand Genetic Position: Chr11, 51.82 cM
• Alliance: Rps6kb1^tm1Nte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155912
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette, inserted in opposite orientation, replaced the exon encoding amino acid residues 207-237 in the p70^s6k protein. The downstream coding region was also frame shifted. Immunological analysis indicated the absence of activity for both the p70 and the p85 isoforms. (J:47608)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rps6kb1 Mutation: 55 strains or lines available

References

• Original: J:47608 Kawasome H, et al., Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5033-8
• All: 4 reference(s)