Ippk^Gt(XA232)Byg
Gene trapped Allele Detail

Summary

• Symbol: Ippk^Gt(XA232)Byg
• Name: inositol 1,3,4,5,6-pentakisphosphate 2-kinase; gene trap XA232, BayGenomics
• MGI ID: MGI:3511861
• Synonyms: Ippk^{Gt(pGT0pfs)1Ucd}
• Gene: Ippk Location: Chr13:49574725-49618049 bp, + strand Genetic Position: Chr13, 25.25 cM
• Alliance: Ippk^Gt(XA232)Byg page

Mutation origin

• Mutant Cell Line: XA232
• Germline Transmission: Earliest citation of germline transmission: J:99722
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0pfs Vector Type: gene trap
• Mutation details: The gene trap vector inserted into the first intron of the gene. RT-PCR analysis on brain mRNA indicated that a transcript containing a fusion between the endogenous gene and the lacZ gene of the gene trap vector is expressed. (J:99722)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XA232	CC144492 ; (MGI Seq Detail)	5' RACE	Chr13:49574870-49574938 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  6 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:

29 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ippk Mutation: 41 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:99722 Verbsky J, et al., Disruption of the mouse inositol 1,3,4,5,6-pentakisphosphate 2-kinase gene, associated lethality, and tissue distribution of 2-kinase expression. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8448-53
• All: 2 reference(s)