Dclre1a^tm1Rleg
Targeted Allele Detail

Summary

• Symbol: Dclre1a^tm1Rleg
• Name: DNA cross-link repair 1A; targeted mutation 1, Randy J Legerski
• MGI ID: MGI:3511952
• Synonyms: Snm1^-
• Gene: Dclre1a Location: Chr19:56517599-56536675 bp, - strand Genetic Position: Chr19, 51.89 cM
• Alliance: Dclre1a^tm1Rleg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94306
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-7 were replaced with a floxed PGKneo cassette inserted in the opposite transcriptional orientation. (J:94306)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dclre1a Mutation: 41 strains or lines available

References

• Original: J:94306 Akhter S, et al., Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress. Mol Cell Biol. 2004 Dec;24(23):10448-55
• All: 2 reference(s)