Ddb2^tm1Pra
Targeted Allele Detail

Summary

• Symbol: Ddb2^tm1Pra
• Name: damage specific DNA binding protein 2; targeted mutation 1, Pradip Raychaudhuri
• MGI ID: MGI:3511965
• Synonyms: DDB2-
• Gene: Ddb2 Location: Chr2:91041917-91067327 bp, - strand Genetic Position: Chr2, 50.56 cM, cytoband E1
• Alliance: Ddb2^tm1Pra page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95633
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 and 5 were replaced with a neomycin selection cassette. Gene expression could not be detected by RT-PCR assay. (J:95633)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ddb2^tm1Pra

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ddb2 Mutation: 38 strains or lines available

References

• Original: J:95633 Yoon T, et al., Tumor-prone phenotype of the DDB2-deficient mice. Oncogene. 2005 Jan 13;24(3):469-78
• All: 6 reference(s)