Thoc1^tm1Dwg
Targeted Allele Detail

Summary

• Symbol: Thoc1^tm1Dwg
• Name: THO complex 1; targeted mutation 1, David W Goodrich
• MGI ID: MGI:3512076
• Synonyms: Thoc1^-
• Gene: Thoc1 Location: Chr18:9958176-9995486 bp, + strand Genetic Position: Chr18, 4.91 cM
• Alliance: Thoc1^tm1Dwg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109614
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-8 were replaced with a neomycin selection cassette. The deletion also causes a frame shift, preventing translation of exons 9-21. Absence of protein product was confirmed by Western blot analysis and qRT-PCR. (J:109614)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thoc1 Mutation: 46 strains or lines available

References

• Original: J:109614 Wang X, et al., Thoc1/Hpr1/p84 is essential for early embryonic development in the mouse. Mol Cell Biol. 2006 Jun;26(11):4362-7
• All: 5 reference(s)