Itga7^tm1Burk
Targeted Allele Detail

Summary

• Symbol: Itga7^tm1Burk
• Name: integrin alpha 7; targeted mutation 1, Dean J Burkin
• MGI ID: MGI:3512077
• Synonyms: alpha7^-, alpha7betagal, alpha7integrin^LacZ
• Gene: Itga7 Location: Chr10:128769645-128794155 bp, + strand Genetic Position: Chr10, 77.2 cM
• Alliance: Itga7^tm1Burk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100236
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a lacZ/neo cassette to permit expression of the beta-galactosidase reporter gene from the alpha7 integrin promoter. Absence of gene product was confirmed by immunohistochemistry, Western blot analysis, and QRT-PCR. (J:100236)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Itga7 Mutation: 35 strains or lines available

References

• Original: J:100236 Flintoff-Dye NL, et al., Role for the alpha7beta1 integrin in vascular development and integrity. Dev Dyn. 2005 Sep;234(1):11-21
• All: 19 reference(s)