Pou4f1^tm1Et
Targeted Allele Detail

Summary

• Symbol: Pou4f1^tm1Et
• Name: POU domain, class 4, transcription factor 1; targeted mutation 1, Eric Turner
• MGI ID: MGI:3512089
• Synonyms: Brn3a^tauLacZ, Brn3a^tlz, Pou4f1^tauLacZ
• Gene: Pou4f1 Location: Chr14:104699112-104705435 bp, - strand Genetic Position: Chr14, 54.21 cM, cytoband E1-E3
• Alliance: Pou4f1^tm1Et page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123264
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: TauLacZ was inserted into the locus along with a floxed neomycin resistance cassette. This caused the deletion of all of the coding sequence of the native gene. The neomycin resistance cassette was subsequently eliminated by Cre-mediated recombination. The ES line was generated in collaboration with Martyn Goulding, Salk Institute. Immunohistochemical analysis confirmed the absence of protein product. (J:123264)

Expression

In Mice Carrying this Mutation:

18 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou4f1 Mutation: 13 strains or lines available

References

• Original: J:123264 Quina LA, et al., Brn3a-expressing retinal ganglion cells project specifically to thalamocortical and collicular visual pathways. J Neurosci. 2005 Dec 14;25(50):11595-604
• All: 17 reference(s)