Nrp1^tm2Ddg
Targeted Allele Detail

Summary

• Symbol: Nrp1^tm2Ddg
• Name: neuropilin 1; targeted mutation 2, David D Ginty
• MGI ID: MGI:3512101
• Synonyms: Npn-1^c, Nrp1^fl, Nrp-1^flox, Nrp1^l/l
• Gene: Nrp1 Location: Chr8:129085085-129229844 bp, + strand Genetic Position: Chr8, 75.78 cM, cytoband E
• Alliance: Nrp1^tm2Ddg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93799
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette was inserted upstream of exon 2 and loxP sites were inserted flanking exon 2 via homologous recombination. The neo cassette was removed by mating with mice expressing germline FlpE recombinase. (J:93799)

Expression

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nrp1 Mutation: 84 strains or lines available

References

• Original: J:93799 Gu C, et al., Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev Cell. 2003 Jul;5(1):45-57
• All: 101 reference(s)