Nrp1^tm2.1Ddg
Targeted Allele Detail

Summary

• Symbol: Nrp1^tm2.1Ddg
• Name: neuropilin 1; targeted mutation 2.1, David D Ginty
• MGI ID: MGI:3512103
• Synonyms: npn-1^-, Nrp1^del
• Gene: Nrp1 Location: Chr8:129085085-129229844 bp, + strand Genetic Position: Chr8, 75.78 cM, cytoband E
• Alliance: Nrp1^tm2.1Ddg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93799
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The floxed region of Nrp1^tm2Ddg containing exon 2 was excised by crossing to mice carrying the Tg(CMV-Cre)1Cgn transgene. (J:93799)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrp1 Mutation: 84 strains or lines available

References

• Original: J:93799 Gu C, et al., Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev Cell. 2003 Jul;5(1):45-57
• All: 8 reference(s)