Rac3^tm1Hkp
Targeted Allele Detail

Summary

• Symbol: Rac3^tm1Hkp
• Name: Rac family small GTPase 3; targeted mutation 1, Nora C Hesterkamp
• MGI ID: MGI:3512107
• Gene: Rac3 Location: Chr11:120612296-120614795 bp, + strand Genetic Position: Chr11, 84.46 cM
• Alliance: Rac3^tm1Hkp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99168
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with a PGK-NEO cassette. QRT-PCR confirmed the absence of gene products. (J:99168)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rac3 Mutation: 13 strains or lines available

References

• Original: J:99168 Cho YJ, et al., Generation of rac3 Null Mutant Mice: Role of Rac3 in Bcr/Abl-Caused Lymphoblastic Leukemia. Mol Cell Biol. 2005 Jul;25(13):5777-85
• All: 2 reference(s)