Prkar1a^tm1.2Lsk
Targeted Allele Detail

Summary

• Symbol: Prkar1a^tm1.2Lsk
• Name: protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1.2, Lawrence Kirschner
• MGI ID: MGI:3512112
• Synonyms: Prkar1a^loxP
• Gene: Prkar1a Location: Chr11:109540231-109560482 bp, + strand Genetic Position: Chr11, 72.33 cM
• Alliance: Prkar1a^tm1.2Lsk page

Prkar1a heterozygosity accelerates osteosarcoma development in Tg(Bglap2-TAg)1Rkho/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98799
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted between exons 1b and 1c and a floxed neomycin resistance cassette was inserted in intron 2. Mice carrying the floxed neomycin resistance cassette were bred to EIIa-cre mice, resulting in removal of the cassette with lox P sites remaining between exons 1b and 1c and in intron 2. (J:98799)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Prkar1a^tm1.2Lsk

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkar1a Mutation: 19 strains or lines available

References

• Original: J:98799 Kirschner LS, et al., A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues. Cancer Res. 2005 Jun 1;65(11):4506-14
• All: 32 reference(s)