Timp1^tm1Pds
Targeted Allele Detail

Summary

• Symbol: Timp1^tm1Pds
• Name: tissue inhibitor of metalloproteinase 1; targeted mutation 1, Paul D Soloway
• MGI ID: MGI:3512125
• Synonyms: Timp1^-, TIMP-1-, TIMP-1KO, TIMP1KO, Timp1^tm1Jae
• Gene: Timp1 Location: ChrX:20736524-20740972 bp, + strand Genetic Position: ChrX, 16.38 cM
• Alliance: Timp1^tm1Pds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43744
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin-thymidine kinase expression cassette resulted in a duplication of part of the gene (the second through the fifth coding exons, with the duplicated copies separated by the selectable markers), and inserted into the third coding exon a 21 bp sequence that placed a stop codon in each reading frame. Northern blot analyses failed to detect transcripts from this allele in lung, ovaries or embryonic fibroblasts. (J:43744, J:94836)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Timp1 Mutation: 15 strains or lines available

References

• Original: J:43744 Soloway PD, et al., Targeted mutagenesis of Timp-1 reveals that lung tumor invasion is influenced by Timp-1 genotype of the tumor but not by that of the host. Oncogene. 1996 Dec 5;13(11):2307-14
• All: 68 reference(s)