Bin3^tm1Gcp
Targeted Allele Detail

Summary

• Symbol: Bin3^tm1Gcp
• Name: bridging integrator 3; targeted mutation 1, George C Prendergast
• MGI ID: MGI:3512131
• Gene: Bin3 Location: Chr14:70337538-70375413 bp, + strand Genetic Position: Chr14, 36.21 cM, cytoband D1
• Alliance: Bin3^tm1Gcp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133313
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Neomycin resistance gene cassette replaces promoter and exon 1. Northern and Western blot analysis confirmed the absence of transcription and protein product. (J:133313)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bin3 Mutation: 18 strains or lines available

References

• Original: J:133313 Ramalingam A, et al., Bin3 deletion causes cataracts and increased susceptibility to lymphoma during aging. Cancer Res. 2008 Mar 15;68(6):1683-90
• All: 2 reference(s)