Bin1^tm2Gcp
Targeted Allele Detail

Summary

• Symbol: Bin1^tm2Gcp
• Name: bridging integrator 1; targeted mutation 2, George C Pendergast
• MGI ID: MGI:3512133
• Synonyms: Bin1^flox
• Gene: Bin1 Location: Chr18:32510283-32568790 bp, + strand Genetic Position: Chr18, 18.01 cM
• Alliance: Bin1^tm2Gcp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117330
• Parent Cell Line: IT2 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites flank exon 3. The 3' loxP site retained in the floxed ES cell line used to generate chimeric mouse includes a point mutant which reduces the efficiency of in vivo recombination ~50%. (J:117330)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bin1 Mutation: 29 strains or lines available

References

• Original: J:117330 Chang MY, et al., Bin1 ablation in mammary gland delays tissue remodeling and drives cancer progression. Cancer Res. 2007 Jan 1;67(1):100-7
• All: 13 reference(s)