Fgf23^tm1Blan
Targeted Allele Detail

Summary

• Symbol: Fgf23^tm1Blan
• Name: fibroblast growth factor 23; targeted mutation 1, Beate Lanske
• MGI ID: MGI:3512143
• Synonyms: Fgf-23^-
• Gene: Fgf23 Location: Chr6:127049865-127058371 bp, + strand Genetic Position: Chr6, 61.92 cM
• Alliance: Fgf23^tm1Blan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94041
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-3 were replaced with lacZ and a neomycin resistance gene. LacZ was cloned in frame downstream of the endogenous initiator methionine. Staining of embryos indicates the mutant gene was expressed in heterozygotes. (J:94041)

Disease models

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf23 Mutation: 18 strains or lines available

References

• Original: J:94041 Sitara D, et al., Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol. 2004 Nov;23(7):421-32
• All: 34 reference(s)