Grin3b^tm1Yaha
Targeted Allele Detail

Summary

• Symbol: Grin3b^tm1Yaha
• Name: glutamate receptor, ionotropic, NMDA3B; targeted mutation 1, Yasunori Hayashi
• MGI ID: MGI:3512173
• Synonyms: NR3B^-
• Gene: Grin3b Location: Chr10:79806549-79813024 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Grin3b^tm1Yaha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126239
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, which contains the initiation codon and sequences encoding the signal peptide, was replaced with a loxP-flanked neomycin selection cassette. The selection cassette was removed through Cre-mediated recombination, leaving a single loxP site in place of exon 1. RT-PCR and in situ hybridization analysis confirmed that no detectable transcript is expressed from this allele. (J:126239)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grin3b Mutation: 36 strains or lines available

References

• Original: J:126239 Niemann S, et al., Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and nonmotoneuronal phenotypes. Eur J Neurosci. 2007 Sep;26(6):1407-20
• All: 1 reference(s)