Cyp2g1^tm1Ding
Targeted Allele Detail

Summary

• Symbol: Cyp2g1^tm1Ding
• Name: cytochrome P450, family 2, subfamily g, polypeptide 1; targeted mutation 1, Xinxin Ding
• MGI ID: MGI:3512181
• Gene: Cyp2g1 Location: Chr7:26508352-26520622 bp, + strand Genetic Position: Chr7, 15.5 cM, cytoband A3
• Alliance: Cyp2g1^tm1Ding page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94380
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a neomycin resistance gene cassette. Absence of transcript expression was confirmed by Northern blot analysis. The inserted neo cassette also reduced the expression of the neighboring Cyp2a5 gene. (J:94380)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp2g1 Mutation: 30 strains or lines available

References

• Original: J:94380 Zhuo X, et al., Targeted disruption of the olfactory mucosa-specific Cyp2g1 gene: impact on acetaminophen toxicity in the lateral nasal gland, and tissue-selective effects on Cyp2a5 expression. J Pharmacol Exp Ther. 2004 Feb;308(2):719-28
• All: 2 reference(s)