Sh2d1a^tm1Vei
Targeted Allele Detail

Summary

• Symbol: Sh2d1a^tm1Vei
• Name: SH2 domain containing 1A; targeted mutation 1, Andre Veillette
• MGI ID: MGI:3512182
• Synonyms: sap^R78A
• Gene: Sh2d1a Location: ChrX:41591442-41610974 bp, + strand Genetic Position: ChrX, 23.2 cM, cytoband A5
• Alliance: Sh2d1a^tm1Vei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93886
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Using a knock-in strategy, arginine 78 in exon 3 was replaced by an alanine. Crossing with EIIa-Cre mice removed a floxed neo. The mutation had no effect on protein abundance. (J:93886)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh2d1a Mutation: 11 strains or lines available

References

• Original: J:93886 Davidson D, et al., Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulation. Immunity. 2004 Nov;21(5):707-17
• All: 6 reference(s)