Mtor^tm1.1Koz
Targeted Allele Detail

Summary

• Symbol: Mtor^tm1.1Koz
• Name: mechanistic target of rapamycin kinase; targeted mutation 1.1, Sara C Kozma
• MGI ID: MGI:3512186
• Synonyms: mTOR^-
• Gene: Mtor Location: Chr4:148533068-148642140 bp, + strand Genetic Position: Chr4, 78.76 cM, cytoband E1
• Alliance: Mtor^tm1.1Koz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94133
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The floxed promoter and exons 1-6 region and the neo cassette were deleted upon crossing with mice expressing Cre recombinase in the germ line. Immunoblot indicated that levels of protein in heterozygote MEFs were approximately half that of wild-type MEFs. (J:94133)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtor Mutation: 115 strains or lines available

References

• Original: J:94133 Gangloff YG, et al., Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol. 2004 Nov;24(21):9508-16
• All: 6 reference(s)