Acvr1c^tm1Cfi
Targeted Allele Detail

Summary

• Symbol: Acvr1c^tm1Cfi
• Name: activin A receptor, type IC; targeted mutation 1, Carlos F Ibanez
• MGI ID: MGI:3512292
• Synonyms: ALK7^-
• Gene: Acvr1c Location: Chr2:58157465-58247907 bp, - strand Genetic Position: Chr2, 33.05 cM
• Alliance: Acvr1c^tm1Cfi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94135
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ reporter gene replaced 739 bp including part of the first exon and intron. No mRNA or protein were detected by RT-PCR or immunoreactivity in the pancreas. LacZ expression was detected in multiple organs (J:94135)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Acvr1c Mutation: 39 strains or lines available

References

• Original: J:94135 Jornvall H, et al., ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse. Mol Cell Biol. 2004 Nov;24(21):9383-9
• All: 10 reference(s)