Pou4f1^tm1Rsd
Targeted Allele Detail

Summary

• Symbol: Pou4f1^tm1Rsd
• Name: POU domain, class 4, transcription factor 1; targeted mutation 1, Michael G Rosenfeld
• MGI ID: MGI:3512302
• Synonyms: Brn-3.0^-
• Gene: Pou4f1 Location: Chr14:104699112-104705435 bp, - strand Genetic Position: Chr14, 54.21 cM, cytoband E1-E3
• Alliance: Pou4f1^tm1Rsd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37118
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A neomycin resistance gene replaced the entire transactivating and critical DNA binding regions. Gene ablation was confirmed by the absence of protein in mutants. (J:37118)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pou4f1 Mutation: 13 strains or lines available

References

• Original: J:37118 McEvilly RJ, et al., Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons. Nature. 1996 Dec 12;384(6609):574-7
• All: 1 reference(s)