Tg(Alb1-Myc)#Sst
Transgene Detail

Summary

• Symbol: Tg(Alb1-Myc)#Sst
• Name: transgene insertion, Snorri S Thorgeirsson
• MGI ID: MGI:3512308
• Synonyms: Alb-c-myc, Alb/c-myc, c-myc
• Transgene: Tg(Alb1-Myc)#Sst Location: unknown
• Alliance: Tg(Alb1-Myc)#Sst page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Alb1-Myc)#Sst expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Myc (MGI:97250)

• Tg(Alb1-Myc)#Sst expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Alb (MGI:87991)

• Mutation details: The insertion of the Myc transgene also deleted approximately 40 kb of chromosome 5 at the insertion site, encompassing sequence downstream of Cyln2 through the first exon of Gtf2ird1. Northern blot and RT-PCR analysis of heart, muscle, liver, and spleen tissue from homozygous mutant mice showed highly reduced levels of Gtf2ird1 transcript. (J:4527)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Alb1-Myc)#Sst

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Four lines were generated: 166.8, 178.3, 181.2, and 179.2 Line 166.8 has a 40kb deletion in the Gtf2ird1 gene, causing a hypomorph allele with craniofacial defects.

References

• Original: J:4527 Murakami H, et al., Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis. Cancer Res. 1993 Apr 15;53(8):1719-23
• All: 6 reference(s)