Npdc1^tm1Ce
Targeted Allele Detail

Summary

• Symbol: Npdc1^tm1Ce
• Name: neural proliferation, differentiation and control 1; targeted mutation 1, C Evrard
• MGI ID: MGI:3512311
• Gene: Npdc1 Location: Chr2:25293067-25299504 bp, + strand Genetic Position: Chr2, 17.23 cM
• Alliance: Npdc1^tm1Ce page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94137
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Beta-galactosidase and neomycin resistance genes were inserted in frame into exon 2 and an AU-rich degradation sequence was inserted 3' of the stop codon. Northern blot using as a probe a fragment corresponding to exon 1 indicated a lack of transcript in mutants. (J:94137)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Npdc1 Mutation: 31 strains or lines available

References

• Original: J:94137 Evrard C, et al., Functional analysis of the NPDC-1 gene. Gene. 2004 Dec 8;343(1):153-63
• All: 2 reference(s)