Txnrd2^tm1.1Marc
Targeted Allele Detail

Summary

• Symbol: Txnrd2^tm1.1Marc
• Name: thioredoxin reductase 2; targeted mutation 1.1, Marcus Conrad
• MGI ID: MGI:3512409
• Synonyms: TrxR2^-
• Gene: Txnrd2 Location: Chr16:18245167-18297823 bp, + strand Genetic Position: Chr16, 11.41 cM
• Alliance: Txnrd2^tm1.1Marc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94136
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Crossing to a cre-deleter strain resulted in excision the 4 floxed exons containing the C-terminal catalytic center. Low levels of a truncated message were detected by RT-PCR (J:94136)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Txnrd2 Mutation: 18 strains or lines available

References

• Original: J:94136 Conrad M, et al., Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol Cell Biol. 2004 Nov;24(21):9414-23
• All: 6 reference(s)