Serpina1b^tm1Jti
Targeted Allele Detail

Summary

• Symbol: Serpina1b^tm1Jti
• Name: serine (or cysteine) preptidase inhibitor, clade A, member 1B; targeted mutation 1, Atsuko Kushi
• MGI ID: MGI:3512411
• Synonyms: alpha1-AT/PI2^-
• Gene: Serpina1b Location: Chr12:103694415-103704448 bp, - strand Genetic Position: Chr12, 52.98 cM
• Alliance: Serpina1b^tm1Jti page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94168
• Parent Cell Line: E14.1TG3B1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• To abolish PI2 isoform transcription, exon 5 was replaced by a 6-kb fragment of human HPRT1. (J:94168)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Serpina1b Mutation: 21 strains or lines available

References

• Original: J:94168 Kushi A, et al., Disruption of the murine alpha1-antitrypsin/PI2 gene. Exp Anim. 2004 Oct;53(5):437-43
• All: 1 reference(s)