Birc6^tm1Sjen
Targeted Allele Detail

Summary

• Symbol: Birc6^tm1Sjen
• Name: baculoviral IAP repeat-containing 6; targeted mutation 1, Stefan Jentsch
• MGI ID: MGI:3512417
• Synonyms: BRUCE^-
• Gene: Birc6 Location: Chr17:74835290-75010351 bp, + strand Genetic Position: Chr17, 45.64 cM, cytoband E3
• Alliance: Birc6^tm1Sjen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94169
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exon 5 and a stop codon introduced into exon 4, thereby eliminating essential portions of the BIR domain. Immunoblot of mutants indicated successful recombination by a lack of protein. (J:94169)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Birc6 Mutation: 240 strains or lines available

References

• Original: J:94169 Lotz K, et al., BRUCE, a giant E2/E3 ubiquitin ligase and inhibitor of apoptosis protein of the trans-Golgi network, is required for normal placenta development and mouse survival. Mol Cell Biol. 2004 Nov;24(21):9339-50
• All: 1 reference(s)