Lgr5^tm1Ah
Targeted Allele Detail

Summary

• Symbol: Lgr5^tm1Ah
• Name: leucine rich repeat containing G protein coupled receptor 5; targeted mutation 1, Aaron Hsueh
• MGI ID: MGI:3512420
• Synonyms: LGR5^-, Lgr5-lacZ, Lgr5^tm1Lex
• Gene: Lgr5 Location: Chr10:115286219-115423685 bp, - strand Genetic Position: Chr10, 63.51 cM
• Alliance: Lgr5^tm1Ah page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94196
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 18, encoding the seven-transmembrane region plus the C-terminal tail, was replaced with an IRES-lacZ-neo cassette via homologous recombination. (J:94196, J:127123)

Disease models

Expression

In Mice Carrying this Mutation:	130 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lgr5 Mutation: 58 strains or lines available

References

• Original: J:94196 Morita H, et al., Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension. Mol Cell Biol. 2004 Nov;24(22):9736-43
• All: 25 reference(s)