Smad2^tm1.1Mwst
Targeted Allele Detail

Summary

• Symbol: Smad2^tm1.1Mwst
• Name: SMAD family member 2; targeted mutation 1.1, Michael Weinstein
• MGI ID: MGI:3512448
• Synonyms: Smad2^flox
• Gene: Smad2 Location: Chr18:76374651-76444034 bp, + strand Genetic Position: Chr18, 51.42 cM
• Alliance: Smad2^tm1.1Mwst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94232
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Crossing Smad2^tm1Mwst with EIIa-cre mice caused the excision of the floxed PGK-neo, leaving exons 9 and 10 flanked with loxP sites. (J:94232)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad2 Mutation: 52 strains or lines available

References

• Original: J:94232 Liu Y, et al., Generation of novel conditional and hypomorphic alleles of the Smad2 gene. Genesis. 2004 Oct;40(2):118-123
• All: 12 reference(s)