Smad2^tm1.2Mwst
Targeted Allele Detail

Summary

• Symbol: Smad2^tm1.2Mwst
• Name: SMAD family member 2; targeted mutation 1.2, Michael Weinstein
• MGI ID: MGI:3512449
• Synonyms: Smad2^deltaE9,10
• Gene: Smad2 Location: Chr18:76374651-76444034 bp, + strand Genetic Position: Chr18, 51.42 cM
• Alliance: Smad2^tm1.2Mwst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94232
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Crossing Smad2^tm1Mwst with EIIa-cre mice caused the excision of exons 9 and 10 and the neomycin cassette. This created a frame shift in exon 11, which encodes part of the MH2 domain. (J:94232)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad2 Mutation: 52 strains or lines available

References

• Original: J:94232 Liu Y, et al., Generation of novel conditional and hypomorphic alleles of the Smad2 gene. Genesis. 2004 Oct;40(2):118-123
• All: 1 reference(s)