Tgfbr2^tm1Sjkm
Targeted Allele Detail

Summary

• Symbol: Tgfbr2^tm1Sjkm
• Name: transforming growth factor, beta receptor II; targeted mutation 1, Seong-Jin Kim
• MGI ID: MGI:3512546
• Synonyms: HT, TbetaR-II
• Gene: Tgfbr2 Location: Chr9:115916763-116004431 bp, - strand Genetic Position: Chr9, 68.39 cM
• Alliance: Tgfbr2^tm1Sjkm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71591
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 of Tgfbr2 was disrupted by using a phosphoglycerate kinase-neo cassette. Gene targeting was confirmed by Northern blot analysis. (J:71591)

Tumor Data

List all tumor models in MMHCdb carrying Tgfbr2^tm1Sjkm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfbr2 Mutation: 40 strains or lines available

References

• Original: J:71591 Im YH, et al., Heterozygous mice for the transforming growth factor-beta type ii receptor gene have increased susceptibility to hepatocellular carcinogenesis. Cancer Res. 2001 Sep 15;61(18):6665-8
• All: 1 reference(s)