Htra2^tm1Jdo
Targeted Allele Detail

Summary

• Symbol: Htra2^tm1Jdo
• Name: HtrA serine peptidase 2; targeted mutation 1, Julian Downward
• MGI ID: MGI:3512633
• Synonyms: HtrA2/Omi^-
• Gene: Htra2 Location: Chr6:83028247-83031552 bp, - strand Genetic Position: Chr6, 35.94 cM
• Alliance: Htra2^tm1Jdo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94227
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P/Ola

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo gene replaced part of exon 1, exons 2 to 6, and part of exon 7 via homologous recombination, removing 83% of the coding sequence including the proteolytic catalytic site. Western blot analysis confirmed absence of protein in MEFs (J:94227)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htra2 Mutation: 20 strains or lines available

References

• Original: J:94227 Martins LM, et al., Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Mol Cell Biol. 2004 Nov;24(22):9848-62
• All: 6 reference(s)