Pias4^tm1Rug
Targeted Allele Detail

Summary

• Symbol: Pias4^tm1Rug
• Name: protein inhibitor of activated STAT 4; targeted mutation 1, Rudolf Grosschedl
• MGI ID: MGI:3512663
• Synonyms: Paisy^-, Paisy-lacZ
• Gene: Pias4 Location: Chr10:80989795-81003554 bp, - strand Genetic Position: Chr10, 39.72 cM, cytoband C1
• Alliance: Pias4^tm1Rug page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94291
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 3' 188 bp of exon 2 and 5150 bp of intron 2 were replaced with a LacZ-PGK-neo inserted in-frame. The deleted sequence included most of the protein domain, including the RING domain. Expression of the PIASy-BetaGal protein was evident in multiple tissues. (J:94291)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pias4 Mutation: 25 strains or lines available

References

• Original: J:94291 Roth W, et al., PIASy-deficient mice display modest defects in IFN and Wnt signaling. J Immunol. 2004 Nov 15;173(10):6189-99
• All: 1 reference(s)