Gabbr1^tm2.1Bet
Targeted Allele Detail

Summary

• Symbol: Gabbr1^tm2.1Bet
• Name: gamma-aminobutyric acid type B receptor subunit 1; targeted mutation 2.1, Bernhard Bettler
• MGI ID: MGI:3512743
• Synonyms: GABAB(1)^-
• Gene: Gabbr1 Location: Chr17:37356888-37385197 bp, + strand Genetic Position: Chr17, 19.16 cM
• Alliance: Gabbr1^tm2.1Bet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94234
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Crossing Gabbr1^tm2Bet with Cre-deleter mice resulted in this allele in which exons 7 and 8 are replaced with a single lox511 site. This region is involved in GABA-binding and the removal of the exons caused a frame shift that prevented translation of the full-length protein. Immunoblot indicated the lack of protein in brain extracts from mutants. (J:94234)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabbr1 Mutation: 73 strains or lines available

References

• Original: J:94234 Haller C, et al., Floxed allele for conditional inactivation of the GABA(B(1)) gene. Genesis. 2004 Nov;40(3):125-30
• All: 2 reference(s)