Rec8^mei8
Chemically induced Allele Detail

Summary

• Symbol: Rec8^mei8
• Name: REC8 meiotic recombination protein; mei8, John Schimenti
• MGI ID: MGI:3512754
• Synonyms: mei8, Rec8^-
• Gene: Rec8 Location: Chr14:55855494-55862852 bp, + strand Genetic Position: Chr14, 28.19 cM
• Alliance: Rec8^mei8 page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94208
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Chemically induced (other) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ES cells were mutagenized using ethyl methansulfonate (EMS), leading to a C-to-T nonsense mutation (GRCm39:chr14:g.55857155C>T) that changes glutamine codon 155 (CAG) in exon 6 (out of 20) to a stop codon (TAG) (p.Q155*). RT-PCR of testes samples from mutants confirmed the lack of transcripts from this allele. (J:94208)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rec8 Mutation: 25 strains or lines available

References

• Original: J:94208 Bannister LA, et al., Positional cloning and characterization of mouse mei8, a disrupted allele of the meiotic cohesin Rec8. Genesis. 2004 Oct 27;40(3):184-194
• All: 16 reference(s)