Mapt^tm1(cre)Nagy
Targeted Allele Detail

Summary

• Symbol: Mapt^tm1(cre)Nagy
• Name: microtubule-associated protein tau; targeted mutation 1, Andras Nagy
• MGI ID: MGI:3512756
• Synonyms: Tau::Cre
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^tm1(cre)Nagy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94203
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Mapt^tm1(cre)Nagy expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mapt (MGI:97180)

• Mutation details: An NLS-Cre-PGK-neo cassette was inserted into exon one, deleting most of the exon 1 coding sequence of the endogenous gene, shifting the start codon site 3 bp downstream and placing it in a partially optimized KOZAK consensus sequence. (J:94203)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mapt (mouse) Summary of all recombinase alleles driven by Mapt. Comparative matrix view of recombinase activities Alliance mouse Mapt gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 430 strains or lines available

References

• Original: J:94203 Korets-Smith E, et al., Cre recombinase specificity defined by the tau locus. Genesis. 2004 Nov;40(3):131-8
• All: 5 reference(s)