Map2^repro4
Chemically induced Allele Detail

Summary

• Symbol: Map2^repro4
• Name: microtubule-associated protein 2; reproductive mutant 4, JAX Reproductive Mutagenesis Program
• MGI ID: MGI:3512900
• Synonyms: G1-397-34, repro4
• Gene: Map2 Location: Chr1:66214432-66481742 bp, + strand Genetic Position: Chr1, 33.49 cM
• Alliance: Map2^repro4 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This phenotypic mutant was identified in an ENU mutagenesis screen. A T to A transversion in an intron located between exons 2 and 3 in ENSMUST00000114015 and ENSMUST00000114017 transcripts, was confirmed by sequencing (J:205107)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map2 Mutation: 109 strains or lines available

Notes

Males are infertile: very low testis weight, no epididymal sperm are recovered. Histological analysis shows arrest of spermatogenesis during late pachytene stage of meiotic prophase, some germ cells appear apoptotic.

References

• Original: J:92463 JAX Reproductive Mutagenesis Program, Heritable mouse mutants from The Jackson Laboratory Reproductive Genomics Mutagenesis Program. MGI Direct Data Submission. 2004-7
• All: 3 reference(s)